Caulobase

Caulobase · a reference for

Caulobacter crescentus

A freshwater bacterium that divides into two different cells: a stalked cell that stays attached and copies its chromosome, and a swimming swarmer cell that must first differentiate before it can. That built-in asymmetry made it a model for how a single cell organises itself in time and space.

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Fig. 1 One cycle, computed frame by frame. Green foci mark the chromosome origin region, the way a fluorescent ParB fusion shows it: one at the old pole, then a copy that crosses to the new pole once replication starts. The traces are schematic levels of each regulator's active form, redrawn qualitatively after Holtzendorff et al. 2004; Collier et al. 2006; Collier et al. 2007; McAdams & Shapiro 2003; they show order and timing, not measured concentrations.

Contents

  1. History35 milestones

    From the stalked bacteria of the 1930s to phase-separated polar condensates: how a pond bacterium became a model for cellular organisation.

  2. Key papers90 papers

    A curated bibliography, every entry checked against PubMed and Crossref, filterable by topic, with BibTeX for all of it.

  3. Datasets & resources61 entries

    Genomes, transcriptomes, ChIP, Tn-seq fitness, Hi-C, methylomes, databases and strains, each with its accession and source paper.

  4. Cell-cycle network34 components · 66 interactions

    The core regulatory circuit, live: follow CtrA, DnaA, GcrA and CcrM through the cycle and open the evidence behind every arrow.

  5. Pathways7 modules

    Chromosome segregation, division-site selection, flagellum and holdfast, c-di-GMP signalling and stress responses, stepped through stage by stage.

  6. Genome browser113 tracks

    The NA1000 chromosome with its annotation, sRNAs, start sites, expression, ChIP, methylation sites, motifs and palindromes, each track with its source.

At a glance

Life cycle
Dimorphic. Every division yields a sessile stalked cell, which can replicate its chromosome at once, and a flagellated swarmer cell, which cannot until it differentiates. source
Habitat
Fresh water; the genus was named in a study of freshwater stalked bacteria (Henrici & Johnson 1935). source
Genome · NA1000
One circular chromosome, 4,042,929 bp, 67.2% GC (RefSeq NC_011916.1). source
Genome · CB15
4,016,947 bp, 67.2% GC (RefSeq NC_002696.2); 3,767 genes in the first annotation (Nierman et al. 2001). source
Essential genome
1,012 essential features at 8-bp resolution, including 480 open reading frames (Christen et al. 2011). source
Cell-cycle transcription
553 genes (19% of the genome) vary with the cell cycle (Laub et al. 2000). source